Aminoacetic acid: preparation and use
Aminoacetic acid (or glycine) is important for the normal functioning of the human body. That is why it is important to consider in more detail the basic physical and chemical properties of the organic matter, pay attention to its use.
Ways to get
First, we will focus on the main ways to obtain glycine. Aminoacetic acid can be obtained by two-stage synthesis.
At the first stage, chloroacetic acid is reacted with chlorine. The main condition for the successful course of this chemical process is the use of a catalyst.
In the second stage, the reaction between the obtained chloroacetic acid and ammonia occurs, the final product will be 2-aminoacetic acid.
Biological value of glycine
This substance is in the composition of many biologically active substances and protein molecules. Aminoacetic acid is a feedstock for the synthesis of purine bases and porphyrins.
What is aminoacetic acid? The formula of the substance is NH2 –CH2 –COOH, which indicates the presence of amphoteric properties.
In many areas of the spinal cord and brain there are receptors for glycine. As it binds to receptors, amino acetic acid has a “inhibitory” effect on neurons. This substance reduces the process of excretion of impulses by neurons, which are “pathogens” of compounds such as glutamic acid.
In addition, glycine binds to individual receptor systems that stimulate signal transmission from aspartate and glutamate neurotransmitters.
Aminoacetic acid in the spinal cord causes inhibition of neurons, therefore it is used in neurology to reduce the increased muscle tone.
Aminoacetic acid reacts with acids, showing its weak basic properties. This reaction is possible due to the presence of an unpaired electron pair on nitrogen in the amino group. The reaction has a donor-acceptor mechanism associated with the formation of salts.
In addition, aminoacetic acid easily reacts with alcohols (esterification), thus forming an ester. It is carried out using concentrated sulfuric acid as a catalyst.
Use in medicine
The pharmacological preparation of amino acetic acid has a sedative (sedative) effect on the patient. Glycine is recognized as a mild tranquilizer, a weak anti-depressant, which allows to reduce the feeling of fear, anxiety, emotional tension.
Glycine is included in the list of substances that positively affect the reduction of alcohol poisoning. As an auxiliary drug, this substance is a nootropic component, helps to improve memory, associative processes.
Glycine stimulates metabolic processes, activates and normalizes the processes of protective inhibition occurring in the central nervous system. When it is used, mental performance increases, and psycho-emotional stress decreases.
Due to its anti-toxic effect, the drug copes with the following tasks:
- reduces aggression, psycho-emotional tension, conflict, increases social adaptation;
- improves mood;
- facilitates sleep and normalizes sleep;
- increases mental performance;
- reduces vegetovascular disorders;
- reduces the toxic effects of alcohol, as well as drugs that negatively affect the central nervous system;
- reduces cerebral disorders in traumatic brain injury, ischemic stroke.
Glycine quickly gets into many biological fluids and tissues of the body, including the brain. This amino acid is metabolized to carbon dioxide and water, it does not accumulate in the tissues.
The analyzed amino acid is recognized as a regulator of metabolic processes. With the systematic use of this substance is observed adrenoblokiruyuschee effect. Often the drug is prescribed to children and adolescents with increased activity, expressed in deviations from normal behavior.