The drug "Diclofenac". Instructions for use. Injections, tablets, ointment and other forms of release
The well-known drug "Diclofenac" refers to a group of non-steroidal anti-inflammatory drugs that have the same mechanism of action on the body. The impact of this group of drugs is carried out on the enzyme cyclooxygenase, which plays a key role in the mechanism of development of the inflammatory process. The result of inflammation is a rise in temperature and the appearance of pain. The action that non-steroidal anti-inflammatory drugs have is aimed at reducing the inflammatory process, reducing the threshold of pain sensitivity and body temperature. The drug "Diclofenac" has a strong anti-inflammatory effect, which led to its wide distribution and use.
Release form and dose
The drug has a wide range of indications, and one dosage form during treatment is simply not enough. Each version contains a detailed instruction, in which everything is indicated, but not a medic in it can be very difficult to understand. The spectrum of choice is simply amazing: these are candles, tablets, solutions for injections, eye drops. The tablets contain 25 or 50 milligrams of active ingredient, as indicated by the instructions for use attached to the drug "Diclofenac". Injections are used only if necessary, mainly with the aim of quickly reducing the temperature, pain syndrome. The most commonly used tablet form, and how to take the pill, tell the doctor, depending on the patient's condition and severity of clinical symptoms. There is also the use of candles, which are introduced by the rectal route. The solutions contain 75 milligrams of the active ingredient of the drug "Diclofenac". Instructions for use injections regulates to do intramuscularly, and the frequency of injection depends on the patient's condition. The gel is applied to the surface of the skin, from which it penetrates the tissues perfectly, and the drops are buried in the eyes.As for pills, they should be taken only after meals.
Adverse reactions and contraindications
Far from being the most innocuous is the drug Diclofenac, during its reception it is possible that many adverse reactions may develop. Impact occurs on the blood and its ability to clot, especially with prolonged use. In this regard, it is worth to beware of taking the drug to persons suffering from bleeding disorders. Care should be taken by those who drink antiplatelet agents, drugs that help improve the rheological properties of blood (such drugs include popular aspirin) or drugs that reduce the ability to thrombosis (for example, the drug Warfarin).
What about the stomach?
Due to the fact that cyclooxygenase activity is suppressed, the gastric mucosa loses its protective properties, especially when taking tablet dosage forms. Gastropathy develops, gastritis worsens, pain increases, especially with peptic ulcer, which can also develop with long-term use of pills. However, today the drug "Diclofenac" is not a threat to the gastric mucosa.The composition of its shell is chosen in such a way that it dissolves in the intestine and does not harm health.
The reaction of the body of the nervous system can manifest pain in the head or insomnia (sleep disturbance). In case of kidney pathology (especially in case of kidney failure) it is undesirable to use the drug, it reduces the amount of urine secreted, due to which edema appears. It is also possible a negative effect on the vessels, due to this there is an increase in blood pressure. It is forbidden to take Diclofenac medicine to pregnant women, as well as women during the feeding period.
The drug can be absorbed quickly and in full, but food intake can impede this process and then it can last from 1 to 4 hours. Removal of 65% of the metabolized drug "Diclofenac" occurs with the help of the kidneys, 1% can be excreted unchanged, and the rest is removed along with the bile, and then with the help of the intestine.
Under what conditions should pay attention to the drug "Diclofenac"?
- Diseases of the musculoskeletal system of an inflammatory nature, mainly rheumatological pathology.The drug can reduce pain and acts symptomatically, it does not affect the progress of the underlying disease.
- To reduce pain, headache, dental or neurological pathology. How "soft" painkiller, which is not addictive, regulates the drug "Diclofenac" instructions for use. Injections may be the only option for the introduction of the drug into the body, especially against the background of inflammation.
- Pathology of the pelvic or ENT organs, in ophthalmology, when diseases are accompanied by an inflammatory process or in the postoperative period. Topical administration of the drug Diclofenac can also be a treatment option for injuries, especially when you need to relieve pain and reduce the inflammatory response.
In what doses can the drug be found in a pharmacy?
The first thing you can find is tablets that dissolve in the intestines, 25, 50 mg each, or a 100 mg long-acting version. Candles are available in 50 and 100 milligrams, application instructions will tell the features of the application attached to the drug "Diclofenac". The injections are represented by a solution in an ampoule, which is intended for insertion into a muscle; 1 milliliter contains 25 milligrams of active ingredient.Gel (5%) and ointment (2%) are used only for external use, one and the other dosage form with a concentration of 1% can also be used. Ophthalmologists widely use eye drops, the concentration of which is equal to 0.1%.
Dose and frequency of use
The drug can be used in various ways, depending on the severity of the condition, but the maximum dose at a time should be no more than 100 mg. Adults take the drug in a dose of 75 to 150 mg per day, but it should be broken up several times. Retard-form can be prescribed and 1 time per day, if necessary, the dose can be increased to 200 mg. When the desired effect is achieved, the consumption of the drug can be reduced to a minimum, due to which stability will be maintained. Children older than six years use the drug "Diclofenac" at the rate of 2 milligrams per kilogram during the day.
Begin use with a dose of 75 milligrams per day (this sometimes requires acute or postoperative conditions), inject the drug into a vein or muscle, the amount can be doubled, but between injections should take at least a couple of hours. Duration of treatment is from one to five days. Rectally, the drug is administered in the form of suppositories (suppositories), 50 mg per day, once or twice.
External use and use in ophthalmology
From 2 to 4 grams of gel or ointment is applied to the skin, and then rubbed into the skin surface. Frequency of use - from 2 to 4 times a day, but after applying it is necessary to thoroughly wash your hands. Eye drops are introduced by instillation (buried in the conjunctival sac). Only one drop is enough 5 times for 3 hours before surgery, after it the dose is one drop - 3 times a day. During rehabilitation, one drop is instilled from 3 to 5 times throughout the day during the entire required period of treatment. If there are other indications, they will require 1 drop of multiplicity from 4 to 5 throughout the day.
Worth paying attention
If Diclofenac is prescribed to patients who have liver problems (chronic hepatitis, compensated cirrhosis), the pharmacokinetic effect and transformation of the drug do not differ from that in a healthy patient. During treatment, it is worthwhile to especially monitor the condition of the liver, regularly examine the picture of peripheral blood and conduct a stool analysis for the content of hidden blood.Perhaps a decrease in mental or motor response of the body.