The drug "Nemulex": instructions for use, analogues, reviews
Next to a man the pain goes throughout his life. With its apparent uselessness and even harmfulness, pain can be said to be on guard of health. It is a kind of indicator that encourages a person to pay attention to himself, his beloved, and to take all possible steps to improve well-being. And if a person - alone or with the attending doctor - moves in the right direction, the painful sensations disappear.
For centuries, people were treated only by the means that nature could offer them (grasses, shrubs, berries, etc.). Today the situation has changed dramatically. To combat pain, many medicines and medicines have been developed that have a different composition and mechanism of action on the human body. One of these drugs is Nemulex. Instructions for use contains a lot of information about the use of the drug and the expected effects.
Pharmacological effects and composition of the drug
Nemux is a broad-spectrum medicine that has a diverse effect on the human body. In the complex, the drug has antipyretic, anti-inflammatory, analgesic and antiagregatny (aggregation - cell sticking into a large multicellular formation) effects. Drugs are attributed to nonsteroidal anti-inflammatory drugs.
Unlike all other drugs of this group, the drug Nemulex selectively has a suppressive effect (inhibits) on COX-2, slows down and completely stops the process of synthesizing prostaglandins in the area of inflammation. At the same time, the influence of Nemulex on COX-1 is expressed to a much lesser extent. As a result, less frequently than other NSAIDs, side effects develop due to inhibition of prostaglandin synthesis in healthy cells and tissues.
The main active component of this drug is nimesulide. One bag in which the Nemulex powder is packaged (the instruction contains complete information on this subject) includes nimesulide in a 100 mg mass fraction.Cremophor A25 (100 mg), anhydrous citric acid (19 mg), aerosil (40 mg), sucrose (1721 mg) and orange flavor (20 mg) act as auxiliary components.
Sphere of influence "Nemuleks"
The drug was developed by scientists for symptomatic treatment. That is, he is able to muffle (or completely block for some time) pain, slow down the development of the inflammatory process for the period of using the medicine. However, the overall progression of the disease "Nemulex" will not have an effect.
Usually, medical workers prescribe "Nemulex" (instructions for use, consumer reviews confirm the feasibility of such an appointment) for diseases, the course of which is accompanied by strong and intense pain. These diseases include arthritis of various etymologies (including rheumatoid), myalgia and arthralgia, tendinitis, bursitis, algomenorrhea, and osteoarthritis.
The drug is able to have a positive effect with headache and dental pain, with pronounced pain in the post-traumatic and postoperative period.
Who is contraindicated "Nemuleks"?
"Nemulex", the use of which is justified in a wide range of pain sensations of different etymologies, however, has a number of contraindications for the purpose and application. It is unacceptable to take medication for people suffering from at the same time bronchial asthma, polyposis (with frequent recurrences) of the nose or paranasal sinuses and intolerance to aspirin (acetylsalicylic acid). Do not prescribe medication to patients with problems in the digestive system, which include erosion and ulceration of the gastric mucosa and duodenum, inflammatory bowel disease during the period of exacerbation, gastrointestinal bleeding.
In addition, "Nemulex" instructions for use prohibits taking people with diseases of the hematopoietic system (hemophilia, clotting). Contraindications to the use of the drug is the patient's chronic heart failure in the stage of decompensation, renal and hepatic failure (as, indeed, any active disease of the liver or kidneys).
The health workers do not prescribe "Nemulex" to those who had a history of hepatotoxic reactions to nimesulide.We must refrain from the use of this drug immediately after the operation for coronary artery bypass surgery. People who suffer from alcoholism and drug addiction, children under 12 years of age, pregnant women and nursing mothers should not take Nemulex.
Who should be careful?
Nemulex itself, its analogues should be taken very, very carefully by people suffering from coronary heart disease, diabetes, cerebrovascular problems, and chronic heart failure. Patients taking Nemulex and suffering from a tendency to develop ulcerative lesions of the gastrointestinal tract should be attentive to themselves. On the background of long-term use of NSAIDs in parallel with anticoagulants, antiplatelet agents, the development of severe somatic diseases is possible. People with diseases of the peripheral arteries, hyperlipidemia (very high blood lipids), elderly patients should also carefully monitor their condition.
The development of adverse effects on the body
A whole list of side effects describes the instructions for use for the drug "Nemulex".The powder can cause a number of negative effects on the part of the digestive system, ranging from nausea, vomiting and constipation to the development of gastrointestinal bleeding, ulcers, and even perforation of the stomach walls. There is the possibility of fulminant hepatitis, jaundice, cholestasis.
Possible reactions from the urinary system, which can manifest in the development of edema, urinary retention, hematuria, renal failure. Occasionally, the reviews of the drug “Nemulex” are referred to as the reason for the appearance in patients of symptoms of oliguria, interstitial nephritis.
In the respiratory system, symptoms of exacerbation of bronchial asthma, impending bronchospasm may appear. The likelihood of shortness of breath. Possible reactions of the cardiovascular system - increased blood pressure, tachycardia, hemorrhage. Negative manifestations of the nervous system can be expressed by dizziness, nightmares, nervousness, fear, drowsiness, encephalopathy. Allergic manifestations in the form of urticaria, angioneurotic shock, anaphylactoid reactions are possible.On the skin may appear rashes, itching, sweating, dermatitis.
In the case of the drug "Nemulex" instructions for use describes the possible reactions from the hematopoietic system. The most common of these are thrombocytopenia, anemia, purpura, lengthening of the bleeding time, pancytopenia. Individual patients talked about blurring visual perception. In the latter case, consultation with an oculist is required.
Nuances of the use of "Nemulex"
In order to minimize the likelihood of side effects, health workers recommend taking Nemux in the minimum effective dosage and for the shortest period. If there is no visible improvement in the process of using the medication, it is necessary to stop taking the medicine and seek medical help. You should also stop taking Nemulex if the body temperature rises against its background and flu-like symptoms develop.
If there are signs of liver damage of varying degrees of intensity (nausea, vomiting, anorexia, abdominal pain, dark-colored urine), doctors also cancel the medication.In the future, these patients are not recommended to use "Nemuleks". It is necessary to stop taking the drug in case of deterioration in the functioning of the kidneys and suspected gastrointestinal bleeding.
If Nemulex granules are used for treatment for more than two weeks, health workers should monitor liver function indicators. Elderly patients develop side effects significantly more often than other groups of patients. The aged people risk getting gastrointestinal bleeding, perforation of the stomach walls, deviations in the work of the heart, liver, kidneys. Such patients should be under the regular clinical supervision of medical personnel.
If a person has a tendency to develop reactions from the nervous system, the optimal solution is to refrain from driving vehicles and other activities that require concentration and increased speed of psychomotor reactions.
Release form "Nemuleks"
Granules - this is the release form of the drug Nemulex. Powder with 100 mg of Nimesulide in a single bag is designed to prepare a suspension and take it inside.Both the granules themselves and the resulting suspension have a light yellow color. Buyers of this anesthetic medicine is offered in cartons. In a pack 2, 4, 6, 10, 20 or 30 bags can be packed. The price increases accordingly with an increase in the number of packages in the package.
Dosing regimen and measures for overdose
As mentioned earlier, the drug is intended for oral administration in the form of a suspension. For its preparation "Nemulex" (powder) from one sachet diluted in water (from 80 to 100 ml). Medical professionals recommend the use of the drug in adult patients and adolescents aged 12 to 18 twice a day, 100 mg each (the contents of one sachet). It is advisable to do this after a meal. The maximum permissible daily dose for all groups of patients is no more than 200 mg of the drug.
Elderly patients do not need to reduce the dose. When deciding how to take Nemulex to people suffering from chronic renal failure, the answer may be the same: the daily dose for such patients should not exceed 100 mg of the drug.
The obvious symptoms of an overdose with Nemulex are nausea, vomiting, apathy, and gastrointestinal bleeding.It is also possible drowsiness, increased blood pressure, respiratory depression. In the absence of adequate medical care may develop renal failure.
Symptomatic and supportive treatment is necessary to eliminate the symptoms of an overdose. There is no special antidote agent. If no more than 4 hours have passed from the moment of taking a large dose of Nemulex, gastric lavage, absorption of an absorbent (usually activated carbon), and an osmotic type laxative will give a good effect. Adult patients can take up to 100 mg of absorbent. In a hospital, these people need to regularly monitor the quality of the functioning of the kidneys and liver.
Information on whether the Nemulex medication can be displayed using hemodialysis does not contain instructions for use. Due to the fact that the degree of binding of nimesulide to proteins is quite high, the procedures of forced diuresis and hemodialysis will not give a positive effect.
In order to minimize the likelihood of overdose and adverse events, health workers prefer to prescribe their patients the minimum effective dose for the shortest possible period.The course of treatment with the use of "Nemuleks" should not last more than two weeks.
Medications of a similar effect
What are the analogs of the drug Nemulex? They can make a fairly large list. First, there is a mass of similar medicines in the form of tablets. These include the following drugs: Aktasulid, Ameolin, Alonil, Aulin, Coxtral, Nise, Nimesan, Nimesulid, Nimulid, Nimika.
Secondly, in addition to this form of release, there are analogues of Nemulex in the form of granules for preparing a suspension (Aulin, Nimesil) and in the form of a ready-made suspension (Nise, Nimulid). Also in the arsenal of modern medicine there are nonsteroidal anti-inflammatory drugs in the form of gels and ointments for external use. These include "Nise", "Sulaidin", "Nimulid."
Unlike such a medication as the medicine Nemulex (the form of release is only granules), many drugs of similar orientation of action and scope of use are produced by manufacturers in several forms at once. For example, "Nise" in pharmacies is offered to patients in the form of tablets, and in the form of a suspension, and in the form of a gel for external use.In the case of Nimesulide, as well as with the Nemulex medicine, the instructions for use recommend that the powder be dissolved in water. In addition to this form of release "Nimesulide" can be purchased at the pharmacy in the form of tablets in various packages. Also in various forms of release, you can purchase an analogue of "Nemuleks" - "Nimulid." Here you can choose from several options: suspension, tablets for oral administration, tablets for sucking, gel for external use.
Reviews of consumers and health workers
Since the drug is used for quite serious and dangerous diseases and can provoke the development of a number of side effects, reviews on Nemulex can be both positive and negative. The majority of positive feedback is associated with the low price of the drug and the rapid onset of the effect of pain relief for a variety of pain sensations. Someone quickly removed headaches, someone took off discomfort with sprains and dislocations of joints. A separate group of consumers says about the excellent effect of the drug for dental pain. Good drug and osteochondrosis, joint pain.Another area where Nemulex has shown itself to be a highly effective drug is a decrease in body temperature in case of catarrhal diseases. Moreover, according to doctors, in these cases the drug acts in a complex way: it has an anti-inflammatory effect, lowers body temperature and has an anesthetic effect.
However, not everything is so rosy. There are patients (and there are quite a few) in whom the reception of Nemulex caused a lot of unpleasant sensations. Someone had drowsiness and hallucinations, someone complained about the appearance of edema, and someone developed a strong allergic reaction in the form of itchy skin.
In general, no matter how well the Nemulex medication was described, the instructions, the testimonials of patients and medical workers, you must love yourself and take a responsible attitude to your health. Correctly assess all risks, take into account all the nuances of the patient's state of health and in accordance with this, only a doctor can choose the dose and develop a regimen. It is for this reason that you can buy medicine at a pharmacy only if you have a prescription. And it is right. Achieving the maximum effect with minimal health risk is the motto for a real doctor, no matter what drug is used - banal ascorbic or powerful,highly effective NSAIDs from the series "Nemulex" and its analogues.